Deleterious Role of TNF- in Retinal Ischemia–Reperfusion Injury
نویسندگان
چکیده
METHODS. Retinal ischemia–reperfusion injury was performed on p55 and p75 knockout (KO) mice and Sprague–Dawley rats using the high intraocular pressure method. The temporal expression of TNFwas ascertained with immunohistochemical staining. Separate rats received intravitreal recombinant TNFor neutralizing antibody before or after ischemia. TUNEL labeling was performed to assess for cell death, and electroretinography was performed to assess function.
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